The lab is working to “re-wire” the RAS pathway to achieve various goals, such as reducing the potency of different RAS mutants and to alter the signal response of the pathway.  These projects are being pursued with one eye toward basic science goals (such as developing a better understanding of RAS pathway input/output relationships), and with one eye toward potential long-term therapeutic options for cancer and for other diseases. 

This work builds on our past work elucidating system-level behaviors of the RAS pathway, mathematically modeling the RAS pathway, and experimental work on the RAS pathway - which has included both making complex measurements and developing new experimental methods.

Several of our current projects in this area involve RAS, the RAS pathway, and cancer because there we have a strong understanding of RAS/RAS pathway systems biology from our previous research, because we have well-validated mathematical models that can help us with the design process, and because we have experimental expertise.